The orders that you have already placed will define the number of your discounts which will be shown in the discount area. While making any order be sure that you use the same e-mail address. Take into account that if your order was placed and then cancelled, the discount for the next order will not be increased.
Another huge problem for Pfizer
Having one of the most epic pharmaceutical failures, Pfizer is going take a charge of 2.8 billion dollars because of weak sales of diabetic drug.
Ranbaxy Laboratories got an import ban to US...
In September this year, the US Food and Drug Administration (FDA) issued an import alert to a third of Ranbaxy Laboratories manufacturing facility in India, because of a quality concernment.
Because of the latest FDA actions, the final dedicated to US market Ranbaxy plant in India was banned to import their products to US. Also the similar import bans are still having the other 2 plants of Ranbaxy in India from 2008 year.
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Orlistat (Tetrahydrolipstatin) capsule
Generic Xenical (also known as Orlistat due to the name of its active ingredient, ornistat) is manufactured by Aurochem Laboratories. Generic Xenical refers to the group of medicines called lipase inhibitors. These medicines are aimed to block the suction of fat coming from food, but not for appetite suppression.
Generic Xenical is a powerful specific and reversible inhibitor of gastrointestinal lipases, which has prolonged action.The drug has high lipophilicity and mixes with fat droplets. Orlistat covalently bounds with the active site of pancreatic and gastric lipases, thereby inactivating them. Because of inhibition of gastrointestinal lipases, triglycerides cannot penetrate into the blood. This creates an energy deficit, which leads to the mobilization of fat stores. Basically, viscero-abdominal fat weight is reduced under the influence of Generic Xenical.
Judging from the results of fat in the feces, orlistat action starts after 24-48 hours after administration. After discontinuation of fat in the stool within 48-72 hours usually returns to the level that took place prior to initiating therapy.
After the receiving it to the gastrointestinal tract associated with gastric and pancreatic lipases, Generic Xenical blocks their effect on fats from food and vitamin esters. Slowing down fat absorption depends on the dose of Generic Xenical. Take the drug at a dose of 360 mg per day (120 mg 3 times a day with meals), about 25 - 30% of fat in the stool output, which corresponds to almost the maximum possible value at the level of stabilization effect. If you increase the dose to more than 120 mg of Generic Xenical, it will not lead to a greater slowdown in fat absorption, received with food. Furthermore we must note that passes through the gastrointestinal tract (in particular the stomach) are slowly, and Generic Xenical are much faster. That is, when taking the medicine with food, it can "turn off" only those enzymes that are released with the first portions of food, and then passing on, are no longer valid. Meanwhile, food arrives later in the duodenum and digests.
Generic Xenical reduces absorption of fat soluble vitamins: β-carotene (vitamin A), α-tocopherol (vitamin E), vitamin K and 30%. Alcohol intake has no effect on the pharmacokinetics and pharmacodynamics of orlistat.
One of side effects is increase of the concentration of the bile acids complex. This complex can have toxic effects on mucous membrane of the colon.
Other well-known side effects reactions can be:
As the blood is absorbed from the intestine of a small amount - less than 1% Generic Xenical, so it has no effect on systemic blood enzymes or enzymes - hepatic lipase. Use of the drug during pregnancy and lactation is undesirable since it leads to a reduced supply of fat soluble vitamins in the body, which is extremely undesirable in pregnancy and lactation.
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